Article
Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association.
The Journal of clinical investigation - 1 Apr 1995
Wilcox D A, Paddock C M, Lyman S, Gill J C, Newman P J
Abstract excerpt
To gain insight into region of the platelet GPIIb-IIIa complex involved in receptor biogenesis and function, we examined the biochemical properties of a defective GPIIb-IIIa complex from patient suffering from type II Glanzmann thrombasthenia. Flow cytometric as well as immunoblot analysis of patient platelets showed significantly reduced levels of GPIIb and GPIIIa compared with a normal control. Patient...
Topics
- Adolescent
- Amino Acid Sequence
- Base Sequence
- Blood Platelets
- Calcium
- Female
- Fibrinogen
- Flow Cytometry
- Humans
- Integrins
- Molecular Sequence Data