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Article

Notch signaling is essential for ventricular chamber development.

Developmental cell - 1 Mar 2007

Grego-Bessa Joaquín, Luna-Zurita Luis, del Monte Gonzalo, Bolós Victoria, Melgar Pedro, Arandilla Alejandro, Garratt Alistair N, Zang Heesuk, Mukouyama Yoh-Suke, Chen Hanying, Shou Weinian, Ballestar Esteban, Esteller Manel, Rojas Ana, Pérez-Pomares José María, de la Pompa José Luis

Abstract excerpt

Ventricular chamber morphogenesis, first manifested by trabeculae formation, is crucial for cardiac function and embryonic viability and depends on cellular interactions between the endocardium and myocardium. We show that ventricular Notch1 activity is highest at presumptive trabecular endocardium. RBPJk and Notch1 mutants show impaired trabeculation and marker expression, attenuated EphrinB2, NRG1, and BMP10...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17336907
DOI: 10.1016/j.devcel.2006.12.011
PMCID: PMC2746361

Genes

NRG1
BMP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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