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Article

Notch signaling is essential for ventricular chamber development.

Developmental cell - 1 Mar 2007

Grego-Bessa Joaquín, Luna-Zurita Luis, del Monte Gonzalo, Bolós Victoria, Melgar Pedro, Arandilla Alejandro, Garratt Alistair N, Zang Heesuk, Mukouyama Yoh-Suke, Chen Hanying, Shou Weinian, Ballestar Esteban, Esteller Manel, Rojas Ana, Pérez-Pomares José María, de la Pompa José Luis

Abstract excerpt

Ventricular chamber morphogenesis, first manifested by trabeculae formation, is crucial for cardiac function and embryonic viability and depends on cellular interactions between the endocardium and myocardium. We show that ventricular Notch1 activity is highest at presumptive trabecular endocardi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17336907
DOI: 10.1016/j.devcel.2006.12.011
PMCID: PMC2746361

Genes

NRG1
BMP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17336907-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Notch signaling is essential for ventricular chamber development.PMID 17336907Read ↗

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Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic EndocardiumSemantic proximity Read ↗

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Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heartSemantic proximity Read ↗

Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular MyocardiumSemantic proximity Read ↗

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Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development.Semantic proximity Read ↗

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