Article
Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump.
Molecular microbiology - 1 May 2013
Janganan Thamarai K, Bavro Vassiliy N, Zhang Li, Borges-Walmsley Maria Inês, Walmsley Adrian R
Abstract excerpt
The MtrCDE multidrug pump, from Neisseria gonorrhoeae, is assembled from the inner and outer membrane proteins MtrD and MtrE, which are connected by the periplasmic membrane fusion protein MtrC. Although it is clear that MtrD delivers drugs to the channel of MtrE, it remains unclear how drug delivery and channel opening are connected. We used a vancomycin sensitivity assay to test for opening of the MtrE channel....
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