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Article

Protein conformational diversity correlates with evolutionary rate.

Molecular biology and evolution - 1 Jul 2013

Javier Zea Diego, Miguel Monzon Alexander, Fornasari Maria Silvina, Marino-Buslje Cristina, Parisi Gustavo

Abstract excerpt

Native state of proteins is better represented by an ensemble of conformers in equilibrium than by only one structure. The extension of structural differences between conformers characterizes the conformational diversity of the protein. In this study, we found a negative correlation between conformational diversity and protein evolutionary rate. Conformational diversity was expressed as the maximum root mean...

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PMID: 23564939
DOI: 10.1093/molbev/mst065

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Source receipt: pubmed, retrieved 7 Sept 2026.

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