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Article

Contractile protein phosphorylation predicts human heart disease phenotypes.

American journal of physiology. Heart and circulatory physiology - 15 Jun 2013

Walker Lori A, Fullerton David A, Buttrick Peter M

Abstract excerpt

Human heart failure has been associated with a low level of thin-filament protein phosphorylation and an increase in calcium sensitivity of contraction relative to both "control" human heart tissue and tissue from small animal models. However, diverse strategies of human tissue procurement and the reliance on tissue obtained from subjects with end-stage heart failure suggest this may be an incomplete...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23564307
DOI: 10.1152/ajpheart.00957.2012
PMCID: PMC3680767

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