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Article

Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure.

Journal of proteome research - 2 Sept 2011

Zhang Jiang, Guy Moltu J, Norman Holly S, Chen Yi-Chen, Xu Qingge, Dong Xintong, Guner Huseyin, Wang Sijian, Kohmoto Takushi, Young Ken H, Moss Richard L, Ge Ying

Abstract excerpt

The rapid increase in the prevalence of chronic heart failure (CHF) worldwide underscores an urgent need to identify biomarkers for the early detection of CHF. Post-translational modifications (PTMs) are associated with many critical signaling events during disease progression and thus offer a plethora of candidate biomarkers. We have employed a top-down quantitative proteomics methodology for comprehensive...

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Identifiers

PMID: 21751783
DOI: 10.1021/pr200258m
PMCID: PMC3170873

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