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Article

Activation of transposable elements during aging and neuronal decline in Drosophila.

Nature neuroscience - 1 May 2013

Li Wanhe, Prazak Lisa, Chatterjee Nabanita, Grüninger Servan, Krug Lisa, Theodorou Delphine, Dubnau Josh

Abstract excerpt

We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

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Source

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Identifiers

PMID: 23563579
DOI: 10.1038/nn.3368
PMCID: PMC3821974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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