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Article

Serial Plasma Comprehensive Genomic Profiling Captures Therapy Resistance and Guides Management of Non-Small Cell Lung Cancer.

Cancer research communications - 1 May 2026

Conroy Michael, Wehr Jaime, Altiery De Jesus Vivian V, Balan Archana, Bowers William, Li Jennifer W, Scott Susan C, Levy Benjamin, Marrone Kristen A, Lam Vincent K, Feliciano Josephine, Hann Christine L, Pabani Aliyah, Naidoo Jarushka, Brahmer Julie R, Forde Patrick M, Anagnostou Valsamo, Murray Joseph C

Abstract excerpt

Plasma comprehensive genomic profiling (pCGP) is implemented in the clinical care of non-small cell lung cancer (NSCLC). Although less well documented, serial pCGP may also guide the management of oncogene-driven NSCLC after first progression. In this study, we assessed the clinical value of serial pCGP, focusing on EGFR-mutant NSCLC. We conducted a retrospective study of 718 patients with NSCLC who underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42001597
DOI: 10.1158/2767-9764.CRC-25-0561
PMCID: PMC13192330

Genes

EGFR
BRAF
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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