Article
Dissecting the roles of the histone chaperones reveals the evolutionary conserved mechanism of transcription-coupled deposition of H3.3.
Nucleic acids research - 1 May 2013
Song Yunkyoung, Seol Ja-Hwan, Yang Jae-Hyun, Kim Hye-Jin, Han Jeung-Whan, Youn Hong-Duk, Cho Eun-Jung
Abstract excerpt
The mammalian genome encodes multiple variants of histone H3 including H3.1/H3.2 and H3.3. In contrast to H3.1/H3.2, H3.3 is enriched in the actively transcribed euchromatin and the telomeric heterochromatins. However, the mechanism for H3.3 to incorporate into the different domains of chromatin...
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