GIGI: an approach to effective imputation of dense genotypes on large pedigrees.

Abstract excerpt

Recent emergence of the common-disease-rare-variant hypothesis has renewed interest in the use of large pedigrees for identifying rare causal variants. Genotyping with modern sequencing platforms is increasingly common in the search for such variants but remains expensive and often is limited to only a few subjects per pedigree. In population-based samples, genotype imputation is widely used so that additional...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Gene Frequency
• Share to Genome, Human