Article
The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2013
Huang Jez, Arsenault Michel, Kann Martin, Lopez-Mendez Carlos, Saleh Monique, Wadowska Dorota, Taglienti Mary, Ho Jacqueline, Miao Yuan, Sims David, Spears Jonathan, Lopez Alfonso, Wright Glenda, Hartwig Sunny
Abstract excerpt
BACKGROUND: The DNA-binding transcription factor Wilms' Tumor Suppressor-1 (WT1) plays an essential role in nephron progenitor differentiation during renal development. We previously used Wt1 chromatin-immunoprecipitation coupled to microarray (ChIP-chip) to identify novel Wt1 target genes that may regulate nephrogenesis in vivo. We discovered that all three members of the SoxC subfamily, namely, Sox4, Sox11, and...
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