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Article

WT1 targetsGas1to maintain nephron progenitor cells by modulating FGF signals

24 Mar 2015

Abstract excerpt

Development of the metanephric kidney depends on tightly regulated interplay between self-renewal and differentiation of a nephron progenitor cell (NPC) pool. Several key factors required for the survival of NPCs have been identified, including fibroblast growth factor (FGF) signaling and the transcription factor Wilms' tumor suppressor 1 (WT1). Here, we present evidence that WT1 modulates FGF signaling by...

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PMID: 25804736
DOI: 10.1242/dev.119735

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