Article
Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).
Kidney international - 1 May 2018
Neirijnck Yasmine, Reginensi Antoine, Renkema Kirsten Y, Massa Filippo, Kozlov Vladimir M, Dhib Haroun, Bongers Ernie M H F, Feitz Wout F, van Eerde Albertien M, Lefebvre Veronique, Knoers Nine V A M, Tabatabaei Mansoureh, Schulz Herbert, McNeill Helen, Schaefer Franz, Wegner Michael, Sock Elisabeth, Schedl Andreas
Abstract excerpt
Congenital abnormalities of the kidney and the urinary tract (CAKUT) belong to the most common birth defects in human, but the molecular basis for the majority of CAKUT patients remains unknown. Here we show that the transcription factor SOX11 is a crucial regulator of kidney development. SOX11 is expressed in both mesenchymal and epithelial components of the early kidney anlagen. Deletion of Sox11 in mice causes...
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