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Structure of a bacterial type III secretion system in contact with a host membrane in situ

11 Dec 2015

Abstract excerpt

Many bacterial pathogens of animals and plants use a conserved type III secretion system (T3SS) to inject virulence effector proteins directly into eukaryotic cells to subvert host functions. Contact with host membranes is critical for T3SS activation, yet little is known about T3SS architecture in this state or the conformational changes that drive effector translocation. Here we use cryo-electron tomography and...

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PMID: 26656452
DOI: 10.1038/ncomms10114

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