Genetic structure of Plasmodium falciparum populations in the Brazilian Amazon region.

doi:10.1086/424601

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Article

Genetic structure of Plasmodium falciparum populations in the Brazilian Amazon region.

The Journal of infectious diseases - 1 Nov 2004

Machado Ricardo L D, Povoa Marinete M, Calvosa Vanja S P, Ferreira Marcelo U, Rossit Andrea R B, dos Santos Eduardo J M, Conway David J

Abstract excerpt

After a major increase in incidence between the 1970s and the 1990s, the Brazilian Amazon region now accounts for the most cases of Plasmodium falciparum malaria in the Americas. Polymorphism of 10 microsatellite loci in the P. falciparum genome was studied in 196 isolates obtained from 5 populations in the region. There was significant multilocus linkage disequilibrium, particularly within populations with lower...

Topics

Animals
Brazil
DNA, Protozoan
Gene Frequency
Genes, Protozoan
Genetic Variation
Genotype
Haplotypes
Heterozygote
Humans
Linkage Disequilibrium
Malaria, Falciparum
Microsatellite Repeats
Molecular Epidemiology
Plasmodium falciparum
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 15478058
DOI: 10.1086/424601

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