Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.

Journal of virology - 1 Jul 2012

Shmulevitz Maya, Gujar Shashi A, Ahn Dae-Gyun, Mohamed Adil, Lee Patrick W K

Abstract excerpt

Reovirus preferentially replicates in transformed cells and is being explored as a cancer therapy. Immunological and physical barriers to virotherapy inspired a quest for reovirus variants with enhanced oncolytic potency. Using a classical genetics approach, we isolated two reovirus variants (T3v1 and T3v2) with superior replication relative to wild-type reovirus serotype 3 Dearing (T3wt) on various human and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid Proteins
Share to Mutant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleotidyltransferases

Share to Oncolytic Viruses

Share to Viral Core Proteins

Share to Viral Load

Share to Viral Plaque Assay

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22532697
DOI: 10.1128/JVI.00304-12
PMCID: PMC3416329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.PMID 22532697Read ↗

Reduction of virion-associated σ1 fibers on oncolytic reovirus variants promotes adaptation toward tumorigenic cells.Semantic proximity Read ↗

Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency In Vitro and In Vivo.Semantic proximity Read ↗

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus StrainsSemantic proximity Read ↗

Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachmentSemantic proximity Read ↗

Exploring Reovirus Plasticity for Improving Its Use as Oncolytic VirusSemantic proximity Read ↗

Activated Ras Signaling Pathways and Reovirus Oncolysis: An Update on the Mechanism of Preferential Reovirus Replication in Cancer CellsSemantic proximity Read ↗

Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines.Semantic proximity Read ↗

Reovirus as a novel oncolytic agentSemantic proximity Read ↗

Modification of mammalian reoviruses for use as oncolytic agentsSemantic proximity Read ↗

Exploring enterovirus pathogenesis and cancer therapy potential through reverse geneticsSemantic proximity Read ↗

Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes.Semantic proximity Read ↗

Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.