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CYP27A1 deficiency promoted osteoclast differentiation

3 Mar 2023

Abstract excerpt

Background: The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but the role of CYP27A1 in osteoclast differentiation has never been explored. Methods: CYP27A1 deficient mice were constructed using CRISPR-Cas9 system. Osteoclast...

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PMID: 36890868
DOI: 10.7717/peerj.15041

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