Article
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2013
Shchors Ksenya, Persson Anders I, Rostker Fanya, Tihan Tarik, Lyubynska Natalya, Li Nan, Swigart Lamorna Brown, Berger Mitchel S, Hanahan Douglas, Weiss William A, Evan Gerard I
Abstract excerpt
Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRas(V12) mouse model crossed into the p53ER(TAM) background, such that either one or both copies of endogenous p53 is replaced by a conditional p53ER(TAM)...
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