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Article

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.

Cardiovascular research - 1 Jul 2013

Memo Massimiliano, Leung Man-Ching, Ward Douglas G, dos Remedios Cristobal, Morimoto Sachio, Zhang Lianfeng, Ravenscroft Gianina, McNamara Elyshia, Nowak Kristen J, Marston Steven B, Messer Andrew E

Abstract excerpt

AIMS: The pure form of familial dilated cardiomyopathy (DCM) is mainly caused by mutations in genes encoding sarcomeric proteins. Previous measurements using recombinant proteins suggested that DCM mutations in thin filament proteins decreased myofibrillar Ca(2+) sensitivity, but exceptions were reported. We re-investigated the molecular mechanism of familial DCM using native proteins. METHODS AND RESULTS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tropomyosin

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Source

Identifiers

PMID: 23539503
DOI: 10.1093/cvr/cvt071

Genes

TPM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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