Article
Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.
Archives of biochemistry and biophysics - 1 Jul 2016
Messer Andrew E, Bayliss Christopher R, El-Mezgueldi Mohammed, Redwood Charles S, Ward Douglas G, Leung Man-Ching, Papadaki Maria, Dos Remedios Cristobal, Marston Steven B
Abstract excerpt
We investigated the effect of 7 Hypertrophic Cardiomyopathy (HCM)-causing mutations in troponin T (TnT) on troponin function in thin filaments reconstituted with actin and human cardiac tropomyosin. We used the quantitative in vitro motility assay to study Ca(2+)-regulation of unloaded movement and its modulation by troponin I phosphorylation. Troponin from a patient with the K280N TnT mutation showed no...
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