Article
Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease.
Hepatology (Baltimore, Md.) - 1 Apr 1999
Asti M, Martinetti M, Zavaglia C, Cuccia M C, Gusberti L, Tinelli C, Cividini A, Bruno S, Salvaneschi L, Ideo G, Mondelli M U, Silini E M
Abstract excerpt
Hepatitis C outcome is likely related both to viral factors and host's immune responses. We correlated the severity of liver disease with human leukocyte antigen (HLA) genes (C4A, C4B, TNFA, TNFB, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, TAP1, and TAP2) in three groups of subjects: 99 patients with chronic hepatitis, 41 asymptomatic carriers, and 179 uninfected controls. Patients with grade/stage 3 to 4 hepatitis...
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