Article
PGD for hereditary breast and ovarian cancer: the route to universal tests for BRCA1 and BRCA2 mutation carriers.
European journal of human genetics : EJHG - 1 Dec 2013
Drüsedau Marion, Dreesen Jos C, Derks-Smeets Inge, Coonen Edith, van Golde Ron, van Echten-Arends Jannie, Kastrop Peter M M, Blok Marinus J, Gómez-García Encarna, Geraedts Joep P, Smeets Hubert J, de Die-Smulders Christine E, Paulussen Aimée D
Abstract excerpt
Preimplantation Genetic Diagnosis (PGD) is a method of testing in vitro embryos as an alternative to prenatal diagnosis with possible termination of pregnancy in case of an affected child. Recently, PGD for hereditary breast and ovarian cancer caused by BRCA1 and BRCA2 mutations has found its way in specialized labs. We describe the route to universal single-cell PGD tests for carriers of BRCA1/2 mutations....
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