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Article

Proof of principle and first cases using preimplantation genetic haplotyping--a paradigm shift for embryo diagnosis.

Reproductive biomedicine online - 1 Jul 2006

Renwick Pamela J, Trussler Jane, Ostad-Saffari Elham, Fassihi Hiva, Black Cheryl, Braude Peter, Ogilvie Caroline Mackie, Abbs Stephen

Abstract excerpt

Preimplantation genetic haplotyping (PGH) proof-of-principle was demonstrated by multiple displacement amplification (MDA) of single buccal cells from a female donor and genotyping using 12 polymorphic markers within the dystrophin gene; the known paternal genotype enabled identification of the paternal haplotype in the MDA products despite 27% allele dropout. MDA amplified DNA from 49 single human blastomeres...

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PMID: 16820122
DOI: 10.1016/s1472-6483(10)62024-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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