Article
Hereditary breast and ovarian cancer and reproduction: an observational study on the suitability of preimplantation genetic diagnosis for both asymptomatic carriers and breast cancer survivors.
Breast cancer research and treatment - 1 Jun 2014
Derks-Smeets Inge A P, de Die-Smulders Christine E M, Mackens Shari, van Golde Ron, Paulussen Aimee D, Dreesen Jos, Tournaye Herman, Verdyck Pieter, Tjan-Heijnen Vivianne C G, Meijer-Hoogeveen Madelon, De Greve Jacques, Geraedts Joep, De Rycke Martine, Bonduelle Maryse, Verpoest Willem M
Abstract excerpt
Preimplantation genetic diagnosis (PGD) is a reproductive option for BRCA1/2 mutation carriers wishing to avoid transmission of the predisposition for hereditary breast and ovarian cancer (HBOC) to their offspring. Embryos obtained by in vitro fertilisation (IVF/ICSI) are tested for the presence of the mutation. Only BRCA-negative embryos are transferred into the uterus. The suitability and outcome of PGD for...
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