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Article

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels.

Blood - 27 Jun 2013

Rydz Natalia, Swystun Laura L, Notley Colleen, Paterson Andrew D, Riches J Jacob, Sponagle Kate, Boonyawat Boonchai, Montgomery Robert R, James Paula D, Lillicrap David

Abstract excerpt

Genetic variation in or near the C-type lectin domain family 4 member M (CLEC4M) has been associated with plasma levels of von Willebrand factor (VWF) in healthy individuals. CLEC4M is a lectin receptor with a polymorphic extracellular neck region possessing a variable number of tandem repeats (VNTR). A total of 491 participants (318 patients with type 1 von Willebrand disease [VWD] and 173 unaffected family...

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Identifiers

PMID: 23529928
DOI: 10.1182/blood-2012-10-457507
PMCID: PMC3722568

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VWF

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