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Article

Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.

Protein engineering, design & selection : PEDS - 1 Sept 2017

Rosenfeld Ronit, Alcalay Ron, Mechaly Adva, Lapidoth Gideon, Epstein Eyal, Kronman Chanoch, J Fleishman Sarel, Mazor Ohad

Abstract excerpt

While potent monoclonal antibodies against ricin were introduced over the years, the question whether increasing antibody affinity enables better toxin neutralization was not fully addressed yet. The aim of this study was to characterize the contribution of antibody affinity to the ricin neutralization potential of the antibody. cHD23 monoclonal antibody that targets the toxin B-subunit and interferes with its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28472478
DOI: 10.1093/protein/gzx028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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