Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of CIC-associated CpG island methylation in oligoastrocytoma.

Neuropathology and applied neurobiology - 1 Dec 2013

Sahm F, Lass U, Herold-Mende C, von Deimling A, Hartmann C, Mueller W

Abstract excerpt

AIMS: Combined deletion of the whole chromosomal arms 1p and 19q is a frequent event in oligodendroglial tumours. Recent identification of recurrent mutations in CIC on 19q and FUBP1 on 1p and their mutational patterns suggest a loss of function of the respective proteins. Surprisingly, oligoastrocytomas harbouring identical genetic characteristics regarding 1p/19q codeletion and frequent IDH1/2 mutations have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Chromosomes, Human, Pair 1
Share to Chromosomes, Human, Pair 19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Genetic Predisposition to Disease

Share to Loss of Heterozygosity

Share to Oligodendroglioma

Source

Identifiers

PMID: 23521081
DOI: 10.1111/nan.12045

Genes

CIC
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of CIC-associated CpG island methylation in oligoastrocytoma.PMID 23521081Read ↗

CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas.Semantic proximity Read ↗

Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.Semantic proximity Read ↗

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.Semantic proximity Read ↗

Loss of CIC and FUBP1 expressions are potential markers of shorter time to recurrence in oligodendroglial tumors.Semantic proximity Read ↗

OligodendrogliomasSemantic proximity Read ↗

CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas.Semantic proximity Read ↗

SNP array analysis reveals novel genomic abnormalities including copy neutral loss of heterozygosity in anaplastic oligodendrogliomas.Semantic proximity Read ↗

Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1.Semantic proximity Read ↗

Chromosomal imbalances detected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomasSemantic proximity Read ↗

Frequent promoter hypermethylation and low expression of the <i>MGMT</i> gene in oligodendroglial tumorsSemantic proximity Read ↗

IDH-Mutant Astrocytoma With Chromosome 19q13 Deletion Manifesting as an Oligodendroglioma-Like Morphology.Semantic proximity Read ↗

Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.