Article
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia.
Blood - 9 May 2013
Teramo Antonella, Gattazzo Cristina, Passeri Francesca, Lico Albana, Tasca Giulia, Cabrelle Anna, Martini Veronica, Frezzato Federica, Trimarco Valentina, Ave Elisa, Boscaro Elisa, Piazza Francesco, Facco Monica, Trentin Livio, Semenzato Gianpietro, Zambello Renato
Abstract excerpt
The JAK/STAT pathway is altered in T-cell large granular lymphocytic leukemia. In all patients, leukemic LGLs display upregulation of phosphorylated STAT3 (P-STAT3) that activates expression of many antiapoptotic genes. To investigate the mechanisms maintaining STAT3 aberrantly phosphorylated using transcriptional protein and functional assays, we analyzed interleukin (IL)-6 and suppressor of cytokine signaling-3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.