Article
Telomere length and elevated iron: the influence of phenotype and HFE genotype.
American journal of hematology - 1 Jun 2013
Mainous Arch G, Wright Robert U, Hulihan Mary M, Twal Waleed O, McLaren Christine E, Diaz Vanessa A, McLaren Gordon D, Argraves W Scott, Grant Althea M
Abstract excerpt
Elevated body iron stores are associated with morbidity and mortality due to oxidative stress. Hereditary hemochromatosis, a common condition caused by HFE gene mutations, can lead to excess iron storage and disease but clinical penetrance of HFE gene mutations is low and many people with elevated iron stores lack HFE mutations. We analyzed data from the Hemochromatosis and Iron Overload Screening Study to assess...
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