Article
Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis.
Bioscience reports - 30 Oct 2020
Martín Maximilino, Millan Andrea, Ferraro Florencia, Tetzlaff Walter F, Lozano Chiappe E, Botta Eliana, Castro Marcelo, Boero Laura, Rey Jorge, Daruich Jorge, Frechtel Gustavo, Meroño Tomas, Cerrone Gloria, Brites Fernando
Abstract excerpt
BACKGROUND: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality. AIM: To evaluate the relationship between ATL and IO in patients with HH. METHODS: Cross-sectional study including 25 patients with HH: 8 with IO and 17 without IO (ferritin < 300 ng/ml) and 25 healthy...
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