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Article

SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2013

Zhao Jing, Mialki Rachel K, Wei Jianxin, Coon Tiffany A, Zou Chunbin, Chen Bill B, Mallampalli Rama K, Zhao Yutong

Abstract excerpt

Rac1, a member of the Rho family of GTPases, regulates diverse cellular functions, including cytoskeleton reorganization and cell migration. F-box proteins are major subunits within the Skp1-Cul1-F-box (SCF) E3 ubiquitin ligases that recognize specific substrates for ubiquitination. The role of F-box proteins in regulating Rac1 stability has not been studied. Mouse lung epithelial (MLE12) cells were used to...

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Identifiers

PMID: 23512198
DOI: 10.1096/fj.12-223099
PMCID: PMC3688740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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