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Article

HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases

4 May 2020

Abstract excerpt

Abstract HACE1 is an E3 ubiquitin ligase with important roles in tumor biology and tissue homeostasis. Loss or mutation of HACE1 has been associated with the occurrence of a variety of neoplasms, but the underlying mechanisms have not been defined yet. Here, we report that HACE1 is frequently mutated in human lung cancer. In mice, loss of Hace1 led to enhanced progression of KRasG12D-driven lung tumors....

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PMID: 32366477
DOI: 10.1158/0008-5472.can-19-2270

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