Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

doi:10.1038/emboj.2012.226

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Article

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

The EMBO journal - 12 Sept 2012

Tadmouri Abir, Kiyonaka Shigeki, Barbado Maud, Rousset Matthieu, Fablet Katell, Sawamura Seishiro, Bahembera Eloi, Pernet-Gallay Karin, Arnoult Christophe, Miki Takafumi, Sadoul Karin, Gory-Faure Sylvie, Lambrecht Caroline, Lesage Florian, Akiyama Satoshi, Khochbin Saadi, Baulande Sylvain, Janssens Veerle, Andrieux Annie, Dolmetsch Ricardo, Ronjat Michel, Mori Yasuo, De Waard Michel

Abstract excerpt

Calcium current through voltage-gated calcium channels (VGCC) controls gene expression. Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription. Electrical activity induces Cacnb4 association to Ppp2r5d, a regulatory subunit of PP2A phosphatase, followed by (i) nuclear translocation of Cacnb4/Ppp2r5d/PP2A, (ii) association with the...

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PMID: 22892567
DOI: 10.1038/emboj.2012.226
PMCID: PMC3442274

Genes

CACNB4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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