Simpute: an efficient solution for dense genotypic data.

Abstract excerpt

Single nucleotide polymorphism (SNP) data derived from array-based technology or massive parallel sequencing are often flawed with missing data. Missing SNPs can bias the results of association analyses. To maximize information usage, imputation is often adopted to compensate for the missing data by filling in the most probable values. To better understand the available tools for this purpose, we compare the...

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