Article
Nonhomologous end joining-mediated gene replacement in plant cells.
Plant physiology - 1 May 2013
Weinthal Dan Michael, Taylor Roslyn Ann, Tzfira Tzvi
Abstract excerpt
Stimulation of the homologous recombination DNA-repair pathway via the induction of genomic double-strand breaks (DSBs) by zinc finger nucleases (ZFNs) has been deployed for gene replacement in plant cells. Nonhomologous end joining (NHEJ)-mediated repair of DSBs, on the other hand, has been utilized for the induction of site-specific mutagenesis in plants. Since NHEJ is the dominant DSB repair pathway and can...
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