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Article

A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responses

8 Sept 2014

Abstract excerpt

Malaria transmission blocking vaccines (TBV) directed against proteins expressed on sexual stages of Plasmodium falciparum in the mosquito midgut are considered an effective means to reduce malaria transmission. Antibodies induced by TBV block sporogonic development in the mosquito, and thus transmission to the next human host. The Pfs25 protein, expressed on the surface of gametes, zygotes and ookinetes, is one...

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PMID: 25483525
DOI: 10.4161/hv.34366

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