Article
A model for studying the hemostatic consumption or destruction of platelets.
PloS one - 1 Jan 2013
Dowling Mark R, Josefsson Emma C, Henley Katya J, Kile Benjamin T, Hodgkin Philip D
Abstract excerpt
A fundamental issue in understanding homeostasis of the hematopoietic system is to what extent intrinsic and extrinsic factors regulate cell fate. We recently revisited this issue for the case of blood platelets and concluded that platelet life span is largely regulated by internal factors, in contrast to the long-held view that accumulated damage from the environment triggers clearance. However, it is known that...
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