The 158VV Fcgamma receptor 3A genotype is associated with response to rituximab in rheumatoid arthritis: results of an Italian multicentre study.

doi:10.1136/annrheumdis-2012-202435

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Article

The 158VV Fcgamma receptor 3A genotype is associated with response to rituximab in rheumatoid arthritis: results of an Italian multicentre study.

Annals of the rheumatic diseases - 1 Apr 2014

Quartuccio Luca, Fabris Martina, Pontarini Elena, Salvin Sara, Zabotti Alen, Benucci Maurizio, Manfredi Mariangela, Biasi Domenico, Ravagnani Viviana, Atzeni Fabiola, Sarzi-Puttini Piercarlo, Morassi Pia, Fischetti Fabio, Tomietto Paola, Bazzichi Laura, Saracco Marta, Pellerito Raffaele, Cimmino Marco, Schiavon Franco, Carraro Valeria, Semeraro Angelo, Caporali Roberto, Cavagna Lorenzo, Bortolotti Roberto, Paolazzi Giuseppe, Govoni Marcello, Bombardieri Stefano, De Vita Salvatore

Abstract excerpt

OBJECTIVE: The polymorphism 158V/F of Fc fragment of IgG (FCGR) type 3A may influence the response to rituximab (RTX) in rheumatoid arthritis (RA). We investigated the FCG3A polymorphism in a large cohort of RA patients treated with RTX, also by considering the possible loss of response from month +4 to +6 after RTX and the presence of established predictors of response. METHODS: The study analysed 212 RA...

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PMID: 23505228
DOI: 10.1136/annrheumdis-2012-202435

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