Article
Association of the FCGR3A-158F/V gene polymorphism with the response to rituximab treatment in Spanish systemic autoimmune disease patients.
DNA and cell biology - 1 Dec 2012
Robledo Gema, Márquez Ana, Dávila-Fajardo Cristina Lucía, Ortego-Centeno Norberto, Rubio José Luis Callejas, Garrido Enrique de Ramón, Sánchez-Román Julio, García-Hernández Francisco J, Ríos-Fernández Raquel, González-Escribano Maria Francisca, García Maria Teresa Camps, Palma Maria Jesús Castillo, Ayala Maria Del Mar, Martín Javier
Abstract excerpt
Rituximab is being used as treatment for systemic autoimmune diseases. The objective of this study was to determine whether the genetic variant in the Fc gamma-receptor III a (FCGR3A) gene, 158F/V, contributes to the observed variation in response to rituximab in patients with systemic autoimmune diseases. DNA samples from 132 Spanish patients with different systemic autoimmune diseases receiving rituximab were...
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