Article
Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2013
Li Lijuan, Wu Jian, Sima Xiutian, Bai Peng, Deng Wei, Deng Xueke, Zhang Lin, Gao Linbo
Abstract excerpt
Growing evidence indicates that tumor suppressor gene TP-53 and non-coding RNA miR-34b/c independently and/or jointly play crucial roles in carcinogenesis. We hypothesized that the polymorphisms of rs4938723 in the promoter region of pri-miR-34b/c and TP-53 Arg72-Pro may be related to the risk of nasopharyngeal carcinoma (NPC). We performed a case-control study between 217 patients with NPC and 360 healthy...
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