Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia.

doi:10.2217/pgs.12.181

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Article

Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia.

Pharmacogenomics - 1 Jan 2013

Hu Miao, Mak Valiant Wl, Xiao Yajie, Tomlinson Brian

Abstract excerpt

AIM: This study examined the associations between the CYP3A4*1G, CYP3A4*22, CYP3A5*3 and PPARA rs4823613 A>G polymorphisms and the phenotypes of CYP3A estimated by the ratio of 6β-hydroxycortisol:cortisol in urine, and the low-density lipoprotein cholesterol response to simvastatin in Chinese patients with hypercholesterolemia. PATIENTS & METHODS: Lipid profiles were determined off treatment and after 6 weeks of...

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PMID: 23252946
DOI: 10.2217/pgs.12.181

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PPARA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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