Article
Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation.
Heart rhythm - 1 Jul 2013
Ling Tian-You, Wang Xiao-Li, Chai Qiang, Lau Tin-Wah, Koestler Celeste M, Park Soon J, Daly Richard C, Greason Kevin L, Jen Jin, Wu Li-Qun, Shen Wei-Feng, Shen Win-Kuang, Cha Yong-Mei, Lee Hon-Chi
Abstract excerpt
BACKGROUND: MicroRNAs are important regulators of gene expression, including those involving electrical remodeling in atrial fibrillation (AF). Recently, KCNN3, the gene that encodes the small-conductance calcium-activated potassium channel 3 (SK3), was found to be strongly associated with AF. OBJECTIVES: To evaluate the changes in atrial myocardial microRNAs in patients with permanent AF and to determine the...
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