Article
[Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 1 Mar 2013
Zheng Miao-Miao, Yue Li-Jie, Chen Xiao-Wen, Wen Fei-Qiu, Li Chang-Gang, Yang Chun-Lan, Xie Cai, Ding Hui
Abstract excerpt
OBJECTIVE: To study the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and toxicities after high-dose methotrexate (HD-MTX) infusion in children with acute lymphocytic leukemia (ALL). METHODS: MTHFR variants in 52 children with ALL were determined by reverse transcriptase-polymerase chain reaction-denaturing gradient gel electrophoresis and sequencing. Toxicities of children...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.