Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of recent natural selection on the Southeast Asian deletion (--(SEA)) causing α-thalassemia in South China.

BMC evolutionary biology - 11 Mar 2013

Qiu Qin-Wei, Wu Dong-Dong, Yu Li-Hua, Yan Ti-Zhen, Zhang Wen, Li Zhe-Tao, Liu Yan-Hui, Zhang Ya-Ping, Xu Xiang-Min

Abstract excerpt

BACKGROUND: The Southeast Asian deletion (--(SEA)) is the most commonly observed mutation among diverse α-thalassemia alleles in Southeast Asia and South China. It is generally argued that mutation --(SEA), like other variants causing hemoglobin disorders, is associated with protection against malaria that is endemic in these regions. However, little evidence has been provided to support this claim. RESULTS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Thalassemia
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Hemoglobins

Share to High-Throughput Nucleotide Sequencing

Share to Malaria

Share to Recombination, Genetic

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23497175
DOI: 10.1186/1471-2148-13-63
PMCID: PMC3626844

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of recent natural selection on the Southeast Asian deletion (--(SEA)) causing α-thalassemia in South China.PMID 23497175Read ↗

The evolutionary origins of Southeast Asian Ovalocytosis.Semantic proximity Read ↗

The Hb H disease genotypes in Southern China.Semantic proximity Read ↗

Genetic origin of α0-thalassemia (SEA deletion) in Southeast Asian populations and application to accurate prenatal diagnosis of Hb Bart's hydrops fetalis syndrome.Semantic proximity Read ↗

Evidence of differential selection for the -α(3.7) and -α(4.2) single-α-globin gene deletions within the same population.Semantic proximity Read ↗

Molecular population genetics of SLC4A1 and Southeast Asian ovalocytosis.Semantic proximity Read ↗

Evaluating the possibility of detecting evidence of positive selection across Asia with sparse genotype data from the HUGO Pan-Asian SNP Consortium.Semantic proximity Read ↗

Natural positive selection and north-south genetic diversity in East Asia.Semantic proximity Read ↗

Epidemiology, evolutionary origin, and malaria-induced positive selection effects of G6PD-deficient alleles in Chinese populations.Semantic proximity Read ↗

Characterising private and shared signatures of positive selection in 37 Asian populations.Semantic proximity Read ↗

Molecular characterization of the--SEA alpha thalassemia allele in Mexican patients with HbH disease.Semantic proximity Read ↗

Prevention of Hb Bart's (γ4) Disease Associated with the - -(THAI) α(0)-Thalassemia Deletion in Mainland China.Semantic proximity Read ↗

A Novel Variant with Positive Natural Selection Influenced Hb A2 Levels in Chinese Individuals with β-Thalassemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.