Article
Molecular characterization of the--SEA alpha thalassemia allele in Mexican patients with HbH disease.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 1 Jan 2000
Nava María Paulina, Trejo Jorge Martín, Aguilar-Luna Carlos, Barros-Núñez Patricio, Chávez M de la Luz, Magaña Maria Teresa, Perea Javier, Ibarra Bertha
Abstract excerpt
Alpha-Thalassemia is one of the most prevalent hemoglobin disorders in the world, in South-East Asians, the --SEA allele is widely found in the HbH disease patients. The purpose of this work is to describe the molecular characteristics of Hemoglobin H disease in three patients from two Mexican families, as well to analyze the DNA sequence of the --SEA allele to determine the precise site of the crossover. The...
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