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Article

Molecular population genetics of SLC4A1 and Southeast Asian ovalocytosis.

Journal of human genetics - 1 Mar 2009

Wilder Jason A, Stone Jonathan A, Preston Elizabeth G, Finn Lauren E, Ratcliffe Hannah L, Sudoyo Herawati

Abstract excerpt

Southeast Asian ovalocytosis (SAO) is an erythrocyte abnormality that protects affected individuals from cerebral malaria. This trait is caused by a 27-bp deletion in the SLC4A1 gene, which is lethal when homozygous. We reseqeunced approximately 5 kb of SLC4A1 in an Indonesian population where SAO is prevalent to better understand the evolution of this clinically important trait. The four SAO chromosomes we...

Topics

Anion Exchange Protein 1, Erythrocyte
Asian People
Base Sequence
Elliptocytosis, Hereditary
Genetic Variation
Genetics, Population
Geography
Haplotypes
Humans
Indonesia
Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Taiwan

Source

Identifiers

PMID: 19229254
DOI: 10.1038/jhg.2009.12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Molecular population genetics of SLC4A1 and Southeast Asian ovalocytosis.PMID 19229254Read ↗

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