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Article

Cell stress molecules in the skeletal muscle of GNE myopathy.

BMC neurology - 12 Mar 2013

Fischer Charlotte, Kleinschnitz Konstanze, Wrede Arne, Muth Ingrid, Kruse Niels, Nishino Ichizo, Schmidt Jens

Abstract excerpt

BACKGROUND: Mutations of the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE)-gene are causally related to GNE myopathy. Yet, underlying pathomechanisms of muscle fibre damage have remained elusive. In sporadic inclusion body myositis (sIBM), the pro-inflammatory cell-stress mediators αB-crystallin and inducible nitric oxide synthase (iNOS) are crucial markers of the disease pathology....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23496965
DOI: 10.1186/1471-2377-13-24
PMCID: PMC3616993

Genes

GNE
APP
CCL4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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