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Article

Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers.

Pharmacogenetics and genomics - 1 May 2013

Dobrinas Maria, Cornuz Jacques, Eap Chin B

Abstract excerpt

BACKGROUND: There is a high interindividual variability in cytochrome P4501A2 (CYP1A2) activity and in its inducibility by smoking, only poorly explained by known CYP1A2 polymorphisms. We aimed to study the contribution of other regulatory pathways, including transcription factors and nuclear receptors, toward this variability. METHODS: CYP1A2 activity was determined by the paraxanthine/caffeine ratio in 184...

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PMID: 23492909
DOI: 10.1097/FPC.0b013e3283602e75

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