Article
Molecular modelling study of antigen binding to oxazolone-specific antibodies: the Ox1 idiotypic IgG and its mature variant with increased affinity to 2-phenyloxazolone.
Protein engineering - 1 Apr 1990
Holm L, Laaksonen L, Kaartinen M, Teeri T T, Knowles J K
Abstract excerpt
Structural models of the variable domains of the murine anti-2-phenyloxazolone IgG (Ox1 idiotype) and its somatic variant, which has higher affinity to the hapten 2-phenyloxazolone, were constructed by computer-aided model building using known structures of highly homologous immunoglobulins as templates. Molecular dynamics simulations were used to dock the hapten between the VL and VH domains. The hapten is...
Topics
- Amino Acid Sequence
- Antibody Affinity
- Antigen-Antibody Reactions
- Antigens
- Binding Sites
- Haptens
- Immunoglobulin G
- Immunoglobulin Idiotypes
- Models, Molecular
- Molecular Sequence Data