Article
Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.
PloS one - 1 Jan 2013
Weber Michael, Lupp Corinna, Stein Pamela, Kreft Andreas, Bopp Tobias, Wehler Thomas C, Schmitt Edgar, Schild Hansjörg, Radsak Markus P
Abstract excerpt
Graft-versus-host disease (GvHD) is a key contributor to the morbidity and mortality after allogeneic hematopoetic stem cell transplantation (HSCT). Regulatory Foxp3(+) CD4(+) T cells (Treg) suppress conventional T cell activation and can control GvHD. In our previous work, we demonstrate that a basic mechanism of Treg mediated suppression occurs by the transfer of cyclic adenosine monophosphate (cAMP) to...
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